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Agmatine sulfate is a biogenic amine stored in the brain’s neurons and is released when these neurons are activated. It is derived from the amino acid L-arginine during decarboxylation reactions, which involves the removal of a carboxyl group. Agmatine sulfate is sometimes considered as a neurotransmitter or neuromodulator. From various studies and clinical trials, agmatine sulfate shows promise as a nootropic that may improve general cognitive health.


The potential agmatine sulfate benefits you may receive are similar to those of arginine, though agmatine sulfate may be more powerful. Research suggests that agmatine sulfate may act as a powerful antioxidant. Antioxidants are designed to neutralize free radicals, a natural product of cellular oxidation. Free radicals can damage and mutate cells, leading to a variety of potential disorders.

Research indicates that agmatine sulfate is a neuroprotective agent. Along with its potential status as an antioxidant, agmatine sulfate may prevent over-activity and excitotxicity induced by excess NMDA and glutamate. Glutamate has also been found to be one of the main neurotransmitters involved in memory function and neuroplasticity. Neuroplasticity refers to your brain’s ability to change and adjust based on new experiences, emotions, and environments. This is essentially your brain’s ability to learn new things and reorganize information. Through agmatine sulfate, you may potentially improve your brain’s learning abilities and memory functions.

Agmatine sulfate may also present benefits for athletes. Studies show that agmatine sulfate may improve the body’s response to insulin, which may then contribute to leaner, harder, and larger muscles. 

Agmatine sulfate has also been observed in some studies to regulate nitric oxide production. Nitric oxide is a molecule naturally produced in the body that plays a role in the transmission of signals between nerve cells in the body. Aging can reduce nitric oxide levels in the body and reduce its overall efficiency. Nitric oxide plays a role in a variety of internal processes, including reducing inflammation, regulating blood pressure, and assisting the immune system. In terms of cognitive processes, nitric oxide has been observed to help memory and behavior.

How to take Agmatine sulfate

As a dietary supplement, take 750 mg (about 1/3 tsp) in a three-day-on, one-day-off cycle (take for three days, but do not take on the fourth day. Then, repeat the cycle). Cycling supplementation prevents the body from building up a tolerance to agmatine, which could diminish or cancel its effects. 

*Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the TGA. Not suitable for children under 18, pregnant or breastfeeding women.

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